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Design and Development of Co-Crystals of Paracetamol and Mefenamic Acid and its Characterization

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Design and Development of Co-Crystals of Paracetamol and Mefenamic Acid and its Characterization


Ketan Tamhane | Gauri Tamboli | Sayali Wagh | Supriya Khatal | Tejaswini Kande | Naziya Sayyad



Ketan Tamhane | Gauri Tamboli | Sayali Wagh | Supriya Khatal | Tejaswini Kande | Naziya Sayyad "Design and Development of Co-Crystals of Paracetamol and Mefenamic Acid and its Characterization" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-4, June 2022, pp.694-698, URL: https://www.ijtsrd.com/papers/ijtsrd50154.pdf

Paracetamol is a class III drug which has limited permeability and High solubility, Mefenamic acid is a class II drug which has High permeability and Low solubility, for overcome this problems co-crystallization method is used. Co-crystallization is the process to enhance the physical properties of drug molecule especially the solubility. Paracetamol is analgesic and mefenamic acid belongs to anti-inflammatory drug (NSAID). Category they are combined for use in tablet formulation. Co-crystallization was used to combine two drugs in single solid phase and thus to achieve new approach for combination therapy. Using the new approach co-crystals of mefenamic acid with Paracetamol was prepared. Co-crystallization of two drugs was carried out by using solvent evaporation and solution co-crystallization method. The saturation solubility was done to evaluate the solubility of co-crystals. Dissolution properties were determined and compared with the marketed tablet formulation. The prepared co-crystals have shown several times faster release than marketed tablet and optimized co-crystals were characterized by using FTIR, Dissolution study.

Paracetamol, Diclofenac, Solvent evaporation, Solution co-crystallization, Characterization


IJTSRD50154
Volume-6 | Issue-4, June 2022
694-698
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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